The mission of the Center for Ophthalmic Optics and Lasers (COOL) is to conserve, improve and restore vision through advances in laser and optical technology.
The Center for Ophthalmic Optics and Lasers (COOL) at Casey Eye Institute, Oregon Health & Science University is a interdisciplinary research center focusing on the application of biomedical optics in clinical medicine. The center has special expertise in two areas: optical coherence tomography (OCT) and laser eye surgery. Among the various eye imaging technologies, OCT has the highest spatial resolution and allows noncontact cross-sectional visualization of internal structures only a few micrometers in thickness. The femtosecond laser and excimer laser allow surgeons to cut and reshape the eye with micrometer control. Using these 2 cutting-edge technologies, the physicians and scientists in the COOL laboratory are working together to diagnose eye diseases with greater accuracy and perform eye surgeries with greater precision.
Dr. David Huang was inducted into the American Ophthalmological Society in May 2014.
Chenxing Zhang is an ophthalmologist in the Southwest eye hospital (西南眼科医院, Chongqing, China). After completing his MD degree in China, he wanted to specialized in cornea thus he applied for a 2-year international research fellowship in the COOL Lab to study corneal surgeries and related clinical research. His application was approved in 2012 and he just completed the fellowship in 2014.
Chenxing’s research work focused on femtosecond laser-assisted corneal surgeries. During his 18 months stay, Chenxing finished one case report about INTACS complication and one journal article about inverted-side cut lamellar keratoplasty as the first author. Meanwhile, he observed varies types of corneal surgeries once every two weeks including PTK, Femto-LASIK, INTACS, IEK, and femtosecond laser-assisted anterior lamellar keratoplasty. He also worked laboratory and clinical studies related to LASIK nomogram design, anterior lamellar keratoplasty, and early keratoconus diagnosis.
Chenxing believes that the experience gained in the COOL Lab will not only be helpful in learning the latest surgical techniques in LASIK and laser-assisted corneal surgeries but also be helpful in future analysis of the large amount of clinical data on LASIK and keratoconus in the Southwest eye hospital.
Dr. David Huang was presented with the Jonas Friedenwald Award at ARVO's 2013 Annual Meetng held in Seattle, WA. The Friedenwald Award is presented annually by the Association for Research in Vision and Ophthalmology (ARVO) to recognize outstanding research in the basic or clinical sciences as applied to ophthalmology.
Dr. Huang was presented wth the award after which he gave the Friedenwald Lecture and spoke on the topic of Structural and Functional Optical Coherence Tomography. The lecture was followed by an award reception which was attended by many friends and colleagues.
See OCT News for more informaton.
Also at ARVO, Dr. Huang's mentor and friend, Dr. James G. Fujimoto, gave the Champalimaud Award Lecture.
David Huang, M.D., Ph.D., Oregon Health & Science University, received the 2012 Champalimaud Vision Award during a ceremony held in Lisbon, Portugal, on September 14, 2012, along with colleagues James G. Fujimoto, Ph.D., Massachusetts Institute of Technology; Carmen A. Puliafito, M.D., M.B.A, University of Southern California; Joel S. Schuman, M.D., FACS, University of Pittsburgh School of Medicine; Eric A. Swanson, M.S., NinePoint Medical, Inc.; and David R. Williams, Ph.D., University of Rochester.
The award was received for developing new approaches to visualizing the living human retina in health and disease: optical coherence tomography, or OCT, and adaptive optics technologies, or AO. The award is often called the "Nobel Prize for Vision" and is the largest monetary prize in the field of vision and one of the largest scientific and humanitarian prizes in the world.
Dr. Huang explains the history and future of OCT in the video:
History and Future of OCT from an Inventor's Perspective
For more information on "The Invention of Optical Coherence Tomography" please see link below:
The Invention of Optical Coherence Tomography
For more information on the Champalimaud Foundation please click:
Champalimaud award recognizes novel approashes to imaging the eye.
Please click on the following links for more information:
Oregon Health & Science University (Press Release)
Advanced Imaging in Glaucoma Study
Dr. Catherine Cleary, MD, a corneal surgeon and a fellow of the Royal College of Surgeons in Ireland, worked in the COOLLab from January to December 2010 while she was a research fellow with Dr David Huang at the Doheny Eye Institute, University of Southern California. During this time she performed research on applications of anterior segment Fourier-Domain OCT combined with femtosecond and excimer lasers to develop novel corneal transplantation techniques. This involved a series of experiments testing novel OCT-guided transplant techniques on eye-bank eyes. Two papers based on this work have been accepted for publication in the journal Cornea. She also worked on OCT applications used in guiding laser treatment of superficial corneal scars and opacities and on guiding accurate femtosecond laser keratotomy incisions for the treatment of high astigmatism following corneal transplantation. Lastly, she collaborated on projects involving Fourier-Domain OCT imaging of the anterior chamber angle. Following her year with the COOLLab, Dr Cleary returned to Ireland where she is now a faculty member at a University Hospital specializing in the treatment of corneal diseases.
In August 2011 Oregon Health & Science University, Casey Eye Institute received a 3.9 million dollar NIH grant entitled “Guiding the treatment of anterior eye disease with optical coherence tomography.” Dr. David Huang, the principal investigator, and other investigators at the Center for Ophthalmic Optics & Lasers (www.coollab.net) will coordinate the multi-center technology development and clinical study efforts. There are four sub-awards in this project: 1) James Fujimoto, PhD, Massachusetts Institute of Technology (engineering site), 2) Douglas Koch, MD, Baylor School of Medicine Cullens Eye Institute, 3) Mark Terry, MD, Legacy Emmanuel Health Center, Devers Eye Institute and 4) Bibiana Jin Reiser, MD, Children's Hospital Los Angeles. This is the second 5 year award for this multiyear project which started in 2007 and ends in 2016. Below is an overview of the project.
Optical coherence tomography (OCT) is a cross-sectional and 3-dimensional (3-D) imaging technology with very fine spatial resolution (5 microns). This project develops the methods and software needed for high-precision OCT measurements of the eye to guide implant, laser and transplant surgeries in the front part of the eye. This NIH grant aims to accurately calculate intraocular lens power and improve outcomes of cataract surgery in eyes with previous laser vision correction and to improve the precision, safety and effectiveness in laser correction of cloudy or irregular corneas and laser-assisted corneal transplantation.
The project aims to develop and utilize a new generation of very high speed OCT (about 10 times faster than previous models, taking an image in as little as 2/1000 of a second). The extended range will enable new types of measurements to be done accurately.
The Specific Aims of the grant are as follows:
(1) To develop ultrahigh-speed OCT hardware and software for measuring optical surfaces of the anterior eye. Intrinsic eye movements effectively limit measurement of corneal shape by commercial OCT. This will be overcome by several approaches, including ultrahigh-speed OCT at 500 kHz, dual-beam OCT to simultaneously capture the shape of both the cornea and the lens, simultaneous capture of Placido-ring videokeratography and motion correction software. The goal is to provide reliable measurements on front and back surfaces of both the cornea and crystalline lens.
(2) To develop an OCT-based intraocular lens power formula. Currently, surgeons lack an accurate way to calculate the precise intraocular lens (IOL) power for cataract patients who have previously had laser vision correction. These patients may be left near- or far-sighted after cataract surgery. An OCT-based IOL formula, using measurements of both anterior and posterior corneal powers, can give surgeons more precise information that will significantly improve visual outcomes. The OCT-based IOL formula will be tested in a clinical trial.
(3) To develop OCT-guided excimer laser surface ablation. The excimer laser can remove cloudy layers from the front of the cornea and correct distorted shape due to keratoconus or transplant surgery. The group has developed 3-D OCT-based planning to optimally remove cloudiness due to corneal scars and stromal dystrophies. This method will be tested in a larger clinical trial. The method will be improved by adding 3-D OCT measurement of corneal shape (topography) to plan the correction of any shape distortion.
(4) To develop OCT-guided laser-assisted anterior and posterior lamellar keratoplasty. Most corneal diseases involve only the inner or outer layer of the cornea. Thus a partial thickness transplant can treat these diseases while avoiding the complications of full-thickness transplantations (rejection, irregular wound shape, etc). However, manual dissection of corneal layers is technically difficult and vision after surgery is limited by the rough interfaces. Therefore, OCT methods have been developed to guide the shaping and smoothing of donor and host corneas with a combination of an excimer laser to create smooth interfaces and a femtosecond laser to create tongue-in-groove edge fits. Pilot clinical trials of these techniques are proposed. The end goal is to develop surgeries that reliably improve the vision in patients with keratoconus, corneal dystrophies and deep scars.
OHSU investigators will work with collaborators at the Massachusetts Institute of Technology and Optovue, Inc. to develop the advanced OCT imaging technology. The clinical studies will be performed at Casey Eye Institute, Cullens Eye Institute, Devers Eye Institute, and Children’s Hospital Los Angeles. The ultimate goal is to improve the precision, visual outcome, and safety of anterior eye surgeries.
The COOL Lab has moved into their newly remodeled lab space on the 3rd floor of the Casey Eye Institute. It is a fabulous space that houses all of our staff and has dry and wet laboratories. We are very fortunate to have a high-tech conference room and a balcony with views of the aerial tram and the mountains.
Thanks to all who made this possible and for those that endured the remodel!